Oxycodone carries quite a few Boxed Warnings for danger of habit, overdose, and Demise; really serious or deadly respiratory depression; fatalities from accidental ingestion by children; lethal Unwanted side effects when utilised with other respiratory depressants or CYP3A4 inhibitors; the potential risk of Neonatal Opioid Withdrawal syndrome in infants born dependent on oxycodone; along with the Opioid Analgesic REMS application.
OXYCONTIN is indicated for that administration of intense and persistent pain that needs an extended treatment method time period having a daily opioid analgesic and for which option cure selections are insufficient in:
Oxycodone must only be utilised when non-opioid analgesics or opioid mixture products haven't been tolerated, are certainly not anticipated to generally be tolerated, or haven't furnished sufficient discomfort aid or will not be anticipated to supply adequate suffering relief.
Tolerance is really a physiological state characterised by a reduced reaction to some drug just after repeated administration (i.e., the next dose of the drug is necessary to supply the same effect that was once obtained at a lessen dose).
To reduce the prospect of choking or acquiring issues swallowing the tablet, get just one a pill at a time if your dose is for multiple pill. Never pre-soak, lick, or moist the tablet before positioning it in the mouth. Make sure you consume plenty of water with Each individual tablet to swallow it wholly.
Separately titrate OXYCONTIN into a dosage that gives suitable analgesia and minimizes adverse reactions. Continuously reevaluate people receiving OXYCONTIN to evaluate the maintenance of soreness Handle, indicators and signs or symptoms of opioid withdrawal, and also other adverse reactions, together with to reassess for the event of dependancy, abuse and misuse [see WARNINGS AND Safety measures].
Notify people that opioids could bring about a unusual but most likely daily life-threatening problem called serotonin syndrome ensuing from concomitant administration of serotonergic medicines.
Evaluate Just about every patient’s risk prior to prescribing OXYCONTIN and observe all patients frequently for more info the development of such behaviors and circumstances [see WARNINGS AND Safeguards].
If a CYP3A4 inhibitor is discontinued, take into consideration escalating the OXYCONTIN dosage check here until finally steady drug effects are achieved. Assess for indications of opioid withdrawal.
If concomitant use is critical, think about expanding the OXYCONTIN dosage until steady drug effects are attained.
Not to be used in kids under eleven many years of age and who're not previously working with opioid discomfort medicines on a regular basis to handle suffering serious sufficient to involve each day all-around-the-clock very long-expression therapy of agony by having an opioid.
Instruct sufferers not to pre-soak, lick, or otherwise soaked OXYCONTIN tablets prior to putting while in the mouth, and also to get just one pill at a time with adequate water to make sure complete swallowing immediately soon after putting within the mouth.
Besides the activities mentioned over, the following have also been described, most likely as a result of swelling and hydrogelling house with the pill: choking, gagging, regurgitation, tablets caught from the throat and issue swallowing the pill.
Oxycodone is actually a managed material Program II, which implies it's got an approved health-related use read more but might lead to critical psychological or physical dependence and has a significant likely for abuse.